Stem cell therapy for Parkinson's disease: where do we stand?

被引：27
作者：
Roybon, L [1 ]
Christophersen, NS [1 ]
Brundin, P [1 ]
Li, JY [1 ]
机构：
[1] Lund Univ, Sect Neuronal Survival, Wallenberg Neurosci Ctr, S-22184 Lund, Sweden
来源：
CELL AND TISSUE RESEARCH | 2004年 / 318卷 / 01期
关键词：
Parkinson's disease; neural grafting; embryonic stem cells; somatic adult stem cells;
D O I：
10.1007/s00441-004-0946-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.
引用
收藏
页码：261 / 273
页数：13
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