Palladium catalyzed cascade umpolung allylation/acetalation for the construction of quaternary 3-amino oxindoles

被引：3

作者：

Sun, Xi-Shang ^{[1
]}

Chang, Xin ^{[1
]}

Shi, Li-Min ^{[1
]}

Wang, Zuo-Fei ^{[1
]}

Wei, Liang ^{[1
]}

Wang, Chun-Jiang ^{[1
,2
]}

机构：

[1] Wuhan Univ, Engn Res Ctr Organosilicon Cpds & Mat, Coll Chem & Mol Sci, Minist Educ, Wuhan 430072, Peoples R China

[2] Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 230021, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 64期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; MARINE ALKALOIDS; NATURAL-PRODUCTS; ALLENES; CYCLOADDITION; CYCLIZATION; ALLYLATION; ANTAGONIST; ARYLATION;

D O I：

10.1039/d1cc03075b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we reported a highly diastereoselective synthesis of quaternary 3-amino oxindoles bearing an acetal unit via a palladium catalyzed three-component cascade umpolung allylation/acetalation process. An array of 3-amino 3-allyl oxindoles incorporating diversified functional groups were prepared in good yields with exclusive diastereoselectivities. Further investigation demonstrated that the current method could also be extended to cascade umpolung allenylation/acetalation.

引用

页码：7958 / 7961

页数：4

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