Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles

被引：123
作者：
Saha, Krishnendu [1 ]
Moyano, Daniel F. [1 ]
Rotello, Vincent M. [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
MATERIALS HORIZONS | 2014年 / 1卷 / 01期
关键词：
IN-VITRO; INTRAVASCULAR HEMOLYSIS; TOXICITY; ASSAYS; SIZE;
D O I：
10.1039/c3mh00075c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The role of nanoparticle surface hydrophobicity on hemolytic properties is established in the absence and presence of plasma proteins. Significantly, the formation of a plasma protein corona on the NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis.
引用
收藏
页码：102 / 105
页数：4
相关论文
共 39 条
  • [11] Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo
    Li, Yuntao
    Liu, Jing
    Zhong, Yuejiao
    Zhang, Jia
    Wang, Ziyu
    Wang, Li
    An, Yanli
    Lin, Mei
    Gao, Zhiqiang
    Zhang, Dongsheng
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 : 2805 - 2819
  • [12] Time Evolution of Nanoparticle-Protein Corona in Human Plasma: Relevance for Targeted Drug Delivery
    Lilia Barran-Berdon, Ana
    Pozzi, Daniela
    Caracciolo, Giulio
    Capriotti, Anna Laura
    Caruso, Giuseppe
    Cavaliere, Chiara
    Riccioli, Anna
    Palchetti, Sara
    Lagana, Aldo
    [J]. LANGMUIR, 2013, 29 (21) : 6485 - 6494
  • [13] Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity
    Lin, Yu-Shen
    Haynes, Christy L.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (13) : 4834 - 4842
  • [14] Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles
    Lin, Yu-Shen
    Haynes, Christy L.
    [J]. CHEMISTRY OF MATERIALS, 2009, 21 (17) : 3979 - 3986
  • [15] Development of screening assays for nanoparticle toxicity assessment in human blood: preliminary studies with charged Au nanoparticles
    Love, Sara A.
    Thompson, John W.
    Haynes, Christy L.
    [J]. NANOMEDICINE, 2012, 7 (09) : 1355 - 1364
  • [16] Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation
    Lu, Senlin
    Duffin, Rodger
    Poland, Craig
    Daly, Paul
    Murphy, Fiona
    Drost, Ellen
    MacNee, William
    Stone, Vicki
    Donaldson, Ken
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2009, 117 (02) : 241 - 247
  • [17] Protein-nanoparticle interactions
    Lynch, Iseult
    Dawson, Kenneth A.
    [J]. NANO TODAY, 2008, 3 (1-2) : 40 - 47
  • [18] Protein-Nanoparticle Interactions: Opportunities and Challenges
    Mahmoudi, Morteza
    Lynch, Iseult
    Ejtehadi, Mohammad Reza
    Monopoli, Marco P.
    Bombelli, Francesca Baldelli
    Laurent, Sophie
    [J]. CHEMICAL REVIEWS, 2011, 111 (09) : 5610 - 5637
  • [19] Monopoli MP, 2012, NAT NANOTECHNOL, V7, P779, DOI [10.1038/NNANO.2012.207, 10.1038/nnano.2012.207]
  • [20] Surface functionalization of nanoparticles for nanomedicine
    Mout, Rubul
    Moyano, Daniel F.
    Rana, Subinoy
    Rotello, Vincent M.
    [J]. CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) : 2539 - 2544
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