Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles

被引：123
作者：
Saha, Krishnendu [1 ]
Moyano, Daniel F. [1 ]
Rotello, Vincent M. [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
MATERIALS HORIZONS | 2014年 / 1卷 / 01期
关键词：
IN-VITRO; INTRAVASCULAR HEMOLYSIS; TOXICITY; ASSAYS; SIZE;
D O I：
10.1039/c3mh00075c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The role of nanoparticle surface hydrophobicity on hemolytic properties is established in the absence and presence of plasma proteins. Significantly, the formation of a plasma protein corona on the NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis.
引用
收藏
页码：102 / 105
页数：4
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