Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles

被引：126

作者：

Saha, Krishnendu ^{[1
]}

Moyano, Daniel F. ^{[1
]}

Rotello, Vincent M. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

MATERIALS HORIZONS | 2014年 / 1卷 / 01期

关键词：

IN-VITRO; INTRAVASCULAR HEMOLYSIS; TOXICITY; ASSAYS; SIZE;

D O I：

10.1039/c3mh00075c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The role of nanoparticle surface hydrophobicity on hemolytic properties is established in the absence and presence of plasma proteins. Significantly, the formation of a plasma protein corona on the NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis.

引用

页码：102 / 105

页数：4

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