Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities

被引：47

作者：

Ibrahim, Sabrin R. M. ^{[1
,2
]}

Mohamed, Gamal A. ^{[3
,4
]}

Al Haidari, Rwaida A. ^{[1
]}

El-Kholy, Amal A. ^{[5
,6
]}

Zayed, Mohamed F. ^{[1
,7
]}

Khayat, Maan T. ^{[8
]}

机构：

[1] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawwarah 30078, Saudi Arabia

[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt

[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia

[4] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut Branch, Assiut 71524, Egypt

[5] Taibah Univ, Coll Pharm, Dept Clin & Hosp Pharm, Al Madinah Al Munawwarah 30078, Saudi Arabia

[6] Ain Shams Univ, Fac Pharm, Dept Clin Pharm, Cairo 11566, Egypt

[7] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt

[8] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia

来源：

FITOTERAPIA | 2018年 / 129卷

关键词：

Fungi; Depsidones; Chemistry; Biosynthesis; Spectral data; Biological activities; DIARYL ETHER DERIVATIVES; ENDOPHYTIC FUNGUS; ASPERGILLUS-UNGUIS; CORYNESPORA-CASSIICOLA; SECONDARY METABOLITES; FUSARIUM-SP; TETRACYCLIC TRITERPENOIDS; CHAETOMIUM-BRASILIENSE; GONGRONEMA-LATIFOLIUM; CHOLESTEROL EFFLUX;

D O I：

10.1016/j.fitote.2018.04.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fungi produce a wide range of structurally unique metabolites. Depsidones represent one of the most interesting classes of metabolites, consisting of two 2,4-dihydroxybenzoic acid rings linked together by both ether and ester bonds. Naturally occurring depsidones are produced by lichen, fungi, and plants. They possessed a wide array of bioactivities, including antioxidant, antiproliferative, antimalarial, cytotoxic, antibacterial, radical scavenging, antihypertensive, anti-inflammatory, antifungal, and aromatase and protein kinase inhibitory. In order to point out the potential of this class of compounds, the present review focuses only on the depsidones that have been isolated from fungal source and published from 1978 to 2018. This review outlined the research on the biosynthesis, source, isolation, spectral and physical data, and bioactivities of the naturally occurring fungal depsidones. On the basis of 88 references, > 80 compounds have been described.

引用

页码：317 / 365

页数：49

共 87 条

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