New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

被引：40

作者：

He, Ke-Yao ^{[1
]}

Zhang, Cheng ^{[1
]}

Duan, Yi-Ru ^{[1
]}

Huang, Guo-Lei ^{[1
]}

Yang, Chun-Yan ^{[1
]}

Lu, Xing-Rui ^{[1
]}

Zheng, Cai-Juan ^{[1
]}

Chen, Guang-Ying ^{[1
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2017年 / 70卷 / 07期

基金：

中国国家自然科学基金;

关键词：

STEMPHYLIUM SP 33231; SOUTH CHINA SEA; DERIVATIVES;

D O I：

10.1038/ja.2017.52

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new chlorinated metabolites 4-chloro-1-hydroxy-3-methoxy-6-methyl-8-methoxycarbonyl-xanthen-9-one (1) and 2'-acetoxy-7-chlorocitreorosein (2), together with three known compounds (3-5), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial and topoisomerase I inhibitory activities. Compound 2 exhibited antibacterial activity against Vibrio parahaemolyticus with an MIC value of 10 mu m.

引用

页码：823 / 827

页数：5

共 19 条

[1] Stimulators of adipogenesis from the marine sponge Xestospongia testudinaria [J].

Akiyama, Takuya ;

Takada, Kentaro ;

Oikawa, Tsutomu ;

Matsuura, Nobuyasu ;

Ise, Yuji ;

Okada, Shigeru ;

Matsunaga, Shigeki .

TETRAHEDRON, 2013, 69 (32) :6560-6564

[2] Additional cytotoxic substances isolated from the sponge-derived Gymnascella dankaliensis [J].

Amagata, Taro ;

Tanaka, Makoto ;

Yamada, Takeshi ;

Chen, Yi-Pei ;

Minoura, Katsuhiko ;

Numata, Atsushi .

TETRAHEDRON LETTERS, 2013, 54 (45) :5960-5962

[3] Marine natural products [J].

Blunt, John W. ;

Copp, Brent R. ;

Keyzers, Robert A. ;

Munro, Murray H. G. ;

Prinsep, Michele R. .

NATURAL PRODUCT REPORTS, 2015, 32 (02) :116-211

[4] ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line [J].

Bogurcu, Nuray ;

Sevimli-Gur, Canan ;

Ozmen, Besra ;

Bedir, Erdal ;

Korkmaz, Kemal Sami .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 409 (04) :738-744

[5]

Fujimoto H, 1996, CHEM PHARM BULL, V44, P1090

[6]

Fujimoto K, 1999, CHEM PHARM BULL, V47, P1426

[7]

Gribble GW., 2010, NATURALLY OCCURRING

[8] Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063 [J].

Huang, Hongbo ;

Wang, Fazuo ;

Luo, Minghe ;

Chen, Yuchan ;

Song, Yongxiang ;

Zhang, Weimin ;

Zhang, Si ;

Ju, Jianhua .

JOURNAL OF NATURAL PRODUCTS, 2012, 75 (07) :1346-1352

[9] Merochlorins A-D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases [J].

Kaysser, Leonard ;

Bernhardt, Peter ;

Nam, Sang-Jip ;

Loesgen, Sandra ;

Ruby, J. Graham ;

Skewes-Cox, Peter ;

Jensen, Paul R. ;

Fenical, William ;

Moore, Bradley S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (29) :11988-11991

[10] Biotransformation of Paeonol and Emodin by Transgenic Crown Galls of Panax quinquefolium [J].

Ma, W. L. ;

Yan, C. Y. ;

Zhu, J. H. ;

Duan, G. Y. ;

Yu, R. M. .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2010, 160 (05) :1301-1308

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