A review of nelfinavir for the treatment of HIV infection

被引：9
作者：
Olmo, Montserrat [1 ]
Podzamczer, Daniel [1 ]
机构：
[1] Hosp Univ Bellvitge, HIV Unit, Infect Dis Serv, Barcelona 08907, Spain
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2006年 / 2卷 / 02期
关键词：
HIV infection; nelfinavir; protease inhibitor;
D O I：
10.1517/17425255.2.2.285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nelfinavir (NFV) is a protease inhibitor that has been widely used for several years for the treatment of HIV infection. This has led to extensive experience with NFV-containing regimens, in which the drug has shown prolonged viral suppression, good tolerability and a unique resistance profile. In recent years, several antiretroviral drugs with some advantages over NFV have been developed. Nevertheless, NFV has favourable characteristics that make it a suitable antiretroviral compound for many HIV-infected patients. It can be used in patients who do not tolerate ritonavir even at low doses, and it is well tolerated in pregnant women, has a low-grade interaction with methadone and may be well tolerated in hepatitis C virus-co-infected patients. In addition, its new simplified posology may contribute to improved adherence.
引用
收藏
页码：285 / 300
页数：16
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