Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy

被引：102

作者：

Liang, Xiaolong ^{[1
]}

Fang, Lei ^{[2
]}

Li, Xiaoda ^{[3
]}

Zhang, Xu ^{[2
]}

Wang, Fan ^{[2
,3
]}

机构：

[1] Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100191, Peoples R China

[2] Peking Univ, Dept Radiat Med, Basic Med Sci, Beijing 100191, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China

来源：

BIOMATERIALS | 2017年 / 132卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Near infrared dye; Cancer theranostics; Photothermal therapy; Multimodal imaging; Hyaluronic acid; INDOCYANINE GREEN; GOLD NANOCAGES; CONTRAST AGENT; PERFLUOROCARBON NANOPARTICLES; POLYPYRROLE NANOPARTICLES; PHOTODYNAMIC THERAPY; FERRITIN NANOCAGES; SURFACE-CHEMISTRY; CANCER-THERAPY; LIVER;

D O I：

10.1016/j.biomaterials.2017.04.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this system, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal nanoprobe, showing great potential for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：72 / 84

页数：13

共 79 条

[1] Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets [J].

Barnett, Brad P. ;

Ruiz-Cabello, Jesus ;

Hota, Partha ;

Ouwerkerk, Ronald ;

Shamblott, Michael J. ;

Lauzon, Cal ;

Walczak, Piotr ;

Gilson, Wesley D. ;

Chacko, Vadappuram P. ;

Kraitchman, Dara L. ;

Arepally, Aravind ;

Bulte, Jeff W. M. .

CONTRAST MEDIA & MOLECULAR IMAGING, 2011, 6 (04) :251-259

[2] Fluorocapsules for Improved Function, Immunoprotection, and Visualization of Cellular Therapeutics with MR, US, and CT Imaging [J].

Barnett, Brad P. ;

Ruiz-Cabello, Jesus ;

Hota, Partha ;

Liddell, Robert ;

Walczak, Piotr ;

Howland, Valerie ;

Chacko, Vadappuram P. ;

Kraitchman, Dara L. ;

Arepally, Aravind ;

Bulte, Jeff W. M. .

RADIOLOGY, 2011, 258 (01) :182-191

[3] Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT) [J].

Beziere, Nicolas ;

Lozano, Neus ;

Nunes, Antonio ;

Salichs, Juan ;

Queiros, Daniel ;

Kostarelos, Kostas ;

Ntziachristos, Vasilis .

BIOMATERIALS, 2015, 37 :415-424

[4] Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity [J].

Boisselier, Elodie ;

Astruc, Didier .

CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) :1759-1782

[5] Model-based optoacoustic inversions with incomplete projection data [J].

Buehler, Andreas ;

Rosenthal, Amir ;

Jetzfellner, Thomas ;

Dima, Alexander ;

Razansky, Daniel ;

Ntziachristos, Vasilis .

MEDICAL PHYSICS, 2011, 38 (03) :1694-1704

[6] Gold Nanocages: A Novel Class of Multifunctional Nanomaterials for Theranostic Applications [J].

Chen, Jingyi ;

Yang, Miaoxin ;

Zhang, Qiang ;

Cho, Eun Chul ;

Cobley, Claire M. ;

Kim, Chulhong ;

Glaus, Charles ;

Wang, Lihong V. ;

Welch, Michael J. ;

Xia, Younan .

ADVANCED FUNCTIONAL MATERIALS, 2010, 20 (21) :3684-3694

[7] Gold Nanocages as Photothermal Transducers for Cancer Treatment [J].

Chen, Jingyi ;

Glaus, Charles ;

Laforest, Richard ;

Zhang, Qiang ;

Yang, Miaoxian ;

Gidding, Michael ;

Welch, Michael J. ;

Xia, Younan .

SMALL, 2010, 6 (07) :811-817

[8] Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy [J].

Chen, Mei ;

Fang, Xiaoliang ;

Tang, Shaoheng ;

Zheng, Nanfeng .

CHEMICAL COMMUNICATIONS, 2012, 48 (71) :8934-8936

[9] In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe [J].

Chen, Xiaoqiang ;

Lee, Dayoung ;

Yu, Sungsook ;

Kim, Gyoungmi ;

Lee, Songyi ;

Cho, Yejin ;

Jeong, Haengdueng ;

Nam, Ki Taek ;

Yoon, Juyoung .

BIOMATERIALS, 2017, 122 :130-140

[10] PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy [J].

Cheng, Liang ;

He, Weiwei ;

Gong, Hua ;

Wang, Chao ;

Chen, Qian ;

Cheng, Zhengping ;

Liu, Zhuang .

ADVANCED FUNCTIONAL MATERIALS, 2013, 23 (47) :5893-5902

← 1 2 3 4 5 6 7 8 →