Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β

被引：20
作者：
Cao, SG
Gao, ZJ
Thomas, SJ
Hecht, SM
Lazo, JS
Kingston, DGI
机构：
[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[2] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA
[3] Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA
[4] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 10期
关键词：
D O I：
10.1021/np049849+
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound I was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.
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页码：1716 / 1718
页数：3
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