Integration of signals to the Arp2/3 complex

被引：154

作者：

Weaver, AM ^{[1
]}

Young, ME ^{[1
]}

Lee, WL ^{[1
]}

Cooper, JA ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Cell Biol, St Louis, MO 63130 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(02)00015-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the known activators. WASPs bind to Arp2/3 via an acidic (A) domain, and a WH2 domain appears to bring an actin monomer to Arp2/3, promoting the nucleation of the new filament. Cortactin also binds the Arp2/3 complex via an A domain; however, it also binds to actin filaments, which helps activate the Arp2/3 complex and stabilise the newly created branches between the filaments.

引用

页码：23 / 30

页数：8

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