Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

被引：80

作者：

Armstrong, Nicola J. ^{[1
,2
]}

Mather, Karen A. ^{[1
]}

Thalamuthu, Anbupalam ^{[1
]}

Wright, Margaret J. ^{[3
,4
]}

Trollor, Julian N. ^{[5
]}

Ames, David ^{[6
,7
]}

Brodaty, Henry ^{[1
,8
]}

Schofield, Peter R. ^{[9
,10
]}

Sachdev, Perminder S. ^{[1
,11
]}

Kwok, John B. ^{[9
,10
,12
]}

机构：

[1] UNSW Australia, Ctr Hlth Brain Aging, Sch Psychiat, Sydney, NSW, Australia

[2] Murdoch Univ, Dept Math & Stat, Perth, WA, Australia

[3] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

[4] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia

[5] UNSW Australia, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia

[6] Univ Melbourne, Acad Unit Psychiat Old Age, Melbourne, Australia

[7] Natl Aging Res Inst, Melbourne, Australia

[8] UNSW Australia, Dementia Collaborat Res Ctr Assessment & Better C, Sydney, NSW, Australia

[9] Neurosci Res Australia, Sydney, NSW, Australia

[10] UNSW Australia, Sch Med Sci, Sydney, NSW, Australia

[11] Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia

[12] Univ Sydney, Brain & Mind Ctr, Camperdown, NSW, Australia

来源：

EPIGENOMICS | 2017年 / 9卷 / 05期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

acceleration; age; aging; centenarians; DNAmage; epigenetic clock; longevity; DNA METHYLATION CHANGES; CPG SITES; AGE; LIFE; SUPERCENTENARIANS; MORTALITY; BLOOD;

D O I：

10.2217/epi-2016-0179

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

引用

页码：689 / 700

页数：12

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