Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L

被引：115

作者：

Di Pietro, R

Zauli, G

机构：

[1] Univ G DAnnunzio, Dipartimento Biomorfol, I-66013 Chieti, Italy

[2] Univ Trieste, Dipartimento Morfol Umana Normale, Trieste, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2004年 / 201卷 / 03期

关键词：

D O I：

10.1002/jcp.20099

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super-family and 21 different receptors have been identified. All ligands of the TNF super-family have been found to activate transcription factor NF-kappaB and c-Jun kinase. Members of this family have diverse biological effects, including induction of apoptosis, promotion of cell survival, and regulation of the immune system and hematopoiesis. The current review focuses on the biological effects of TNF-related apoptosis-inducing ligand (TRAIL), a TNF super-family member which, a few years ago, generated considerable enthusiasm for its anticancer activity, not accompanied by general toxicity in most normal tissues and organs. (C) 2004 Wiley-Liss, Inc.

引用

收藏

页码：331 / 340

页数：10

相关论文

共 111 条

[11]

Bouillet P, 2002, J CELL SCI, V115, P1567

[12] Regulation of cell death protease caspase-9 by phosphorylation [J].

Cardone, MH ;

Roy, N ;

Stennicke, HR ;

Salvesen, GS ;

Franke, TF ;

Stanbridge, E ;

Frisch, S ;

Reed, JC .

SCIENCE, 1998, 282 (5392) :1318-1321

[13] Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway [J].

Chaudhary, PM ;

Eby, M ;

Jasmin, A ;

Bookwalter, A ;

Murray, J ;

Hood, L .

IMMUNITY, 1997, 7 (06) :821-830

[14] Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis [J].

Chawla-Sarkar, M ;

Lindner, DJ ;

Liu, YF ;

Williams, B ;

Sen, GC ;

Silverman, RH ;

Borden, EC .

APOPTOSIS, 2003, 8 (03) :237-249

[15] Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer [J].

Chen, XF ;

Thakkar, H ;

Tyan, F ;

Gim, S ;

Robinson, H ;

Lee, C ;

Pandey, SK ;

Nwokorie, C ;

Onwudiwe, N ;

Srivastava, RK .

ONCOGENE, 2001, 20 (42) :6073-6083

[16]

Chen XF, 2003, CANCER RES, V63, P1059

[17] Enhanced proliferation and increased IFN-γ production in T cells by signal transduced through TNF-related apoptosis-inducing ligand [J].

Chou, AH ;

Tsai, HF ;

Lin, LL ;

Hsieh, SL ;

Hsu, PI ;

Hsu, PN .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1347-1352

[18] Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappa B control [J].

Chu, ZL ;

McKinsey, TA ;

Liu, L ;

Gentry, JJ ;

Malim, MH ;

Ballard, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10057-10062

[19] Reovirus-induced apoptosis is mediated by TRAIL [J].

Clarke, P ;

Meintzer, SM ;

Gibson, S ;

Widmann, C ;

Garrington, TP ;

Johnson, GL ;

Tyler, KL .

JOURNAL OF VIROLOGY, 2000, 74 (17) :8135-8139

[20] Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells [J].

Clodi, K ;

Wimmer, D ;

Li, Y ;

Goodwin, R ;

Jaeger, U ;

Mann, G ;

Gadner, H ;

Younes, A .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (02) :580-586

← 1 2 3 4 5 6 7 8 9 10 →