Prognostic value of metabolic parameters on 18F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma

被引：9

作者：

Choi, Byung Wook ^{[1
]}

Kang, Sungmin ^{[1
]}

Bae, Sung Uk ^{[2
]}

Jeong, Woon Kyung ^{[2
]}

Baek, Seong Kyu ^{[2
]}

Song, Bong-Il ^{[3
]}

Won, Kyoung Sook ^{[3
]}

Kim, Hae Won ^{[3
]}

机构：

[1] Daegu Catholic Univ, Med Ctr, Sch Med, Dept Nucl Med, Daegu, South Korea

[2] Keimyung Univ, Sch Med, Dongsan Hosp, Div Colorectal Surg,Dept Surg, Daegu, South Korea

[3] Keimyung Univ, Dongsan Hosp, Sch Med, Dept Nucl Med, 1035 Dalgubeol Daero, Daegu, South Korea

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

TOTAL LESION GLYCOLYSIS; COLORECTAL-CANCER; FDG-PET/CT; EMISSION-TOMOGRAPHY; F-18-FDG PET/CT; TUMOR VOLUME; COMPUTED TOMOGRAPHY; SURVIVAL; CHEMOTHERAPY; PRETREATMENT;

D O I：

10.1038/s41598-021-92118-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We aimed to investigate the prognostic value of the metabolic parameters of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in classical rectal adenocarcinoma (CRAC). We retrospectively reviewed 149 patients with CRAC who underwent preoperative F-18-FDG PET/CT at initial diagnosis followed by curative surgical resection. F-18-FDG PET/CT metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) for disease-free survival (DFS) and overall survival (OS) were evaluated for prognostic significance by univariate and multivariate analyses, along with conventional risk factors including pathologic T (pT) stage, lymph node (LN) metastasis, lymphovascular invasion (LVI), perineural invasion (PNI), and preoperative carcinoembryonic antigen (CEA) level. On univariate analysis, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG were significant prognostic factors affecting DFS (all P<0.05), while CEA level, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG affected OS (all P<0.05). On multivariate analysis, positive LN metastasis, LVI, MTV, and TLG were independent prognostic factors affecting DFS (all P<0.05), while CEA level, positive LN metastasis, and MTV affected OS (all P<0.05). Thus, the volume-based metabolic parameters from preoperative F-18-FDG PET/CT scans are independent prognostic factors in patients with CRAC.

引用

页数：10

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