Muller cells upregulate the expression of SAP97 in light-injured rat retina

被引：4

作者：

Ren, Hui ^{[1
]}

Xu, Gezhi ^{[1
,2
]}

Qian, Jiang ^{[1
]}

Zhou, Min ^{[1
]}

Gonzales, John ^{[3
]}

Ni, Yingqin ^{[1
]}

机构：

[1] Fudan Univ, EENT Hosp, Inst Eye, Shanghai 200031, Peoples R China

[2] Fudan Univ, Inst Brain Sci, Shanghai 200031, Peoples R China

[3] Univ Texas Med Branch, Dept Ophthalmol & Visual Sci, Galveston, TX USA

来源：

NEUROREPORT | 2010年 / 21卷 / 12期

关键词：

aquaporin; blue light injury; Kir4.1; Muller cell; outer retinal edema; SAP97; TUMOR-SUPPRESSOR PROTEIN; POTASSIUM CHANNEL; PRESYNAPTIC PROTEIN; KIR4.1; PSD-95/SAP90; DEGENERATION; HOMOLOG; DOMAINS; NEURONS; CLONING;

D O I：

10.1097/WNR.0b013e32833d40ab

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the Muller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the Muller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina. NeuroReport 21:832-836 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：832 / 836

页数：5

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