Can bone marrow cellularity help in predicting prognosis in myelodysplastic syndromes?

被引：10

作者：

Greenbaum, Uri ^{[1
,2
]}

Joffe, Erel ^{[3
,4
]}

Filanovsky, Kalman ^{[5
,6
]}

Oster, Howard S. ^{[4
,7
]}

Kirgner, Ilya ^{[4
,7
]}

Levi, Itai ^{[1
,2
]}

Raanani, Pia ^{[3
,4
]}

Avivi, Irit ^{[4
,7
]}

Manor, Esther ^{[1
,2
]}

Man-El, Gili ^{[4
]}

Mittelman, Moshe ^{[4
,7
]}

机构：

[1] Soroka Med Ctr, Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Beer Sheva, Israel

[3] Rabin Med Ctr, Davidoff Canc Ctr, Petah Tiqwa, Israel

[4] Tel Aviv Univ, Sackler Med Sch, Tel Aviv, Israel

[5] Kaplan Med Ctr, Rehovot, Israel

[6] Hadassah Med Sch, Jerusalem, Israel

[7] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2018年 / 101卷 / 04期

关键词：

bone marrow cellularity; bone marrow failure; MDS; myelodysplastic syndromes; prediction modeling in cancer; WORLD-HEALTH-ORGANIZATION; SCORING SYSTEM; MYELOID NEOPLASMS; CLASSIFICATION; RISK; PARAMETERS; PROPOSALS; DIAGNOSIS; INFERENCE; REVISION;

D O I：

10.1111/ejh.13134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To ascertain the relevance of bone marrow cellularity (BMC) to the interpretation of blast percentage (blast%) in MDS prognostication. Methods: We compared survival prediction based on blast% adjusted to different levels of cellularity, compared to the survival based on the original IPSS-R blast% grouping. Results: We analyzed 355 consecutive MDS patients. Cellularity, in arid of itself or its interaction with blast%, was not associated with overall survival (OS). In a small subset of patients with a hypercellular marrow (15%; n = 26), dismal prognosis was observed at lower levels of blast%. For these cases OS was similar to higher IPSS-R blast groups. For example, within the Intermediate group (blast% 5%-10%), those with a hypercellular marrow and >6% blasts had an OS of 10 m similar to 16 m in the High (blast% 10%-19%) blast group. These changes did not translate into a significant improvement in overall prognostic power of a cellularity-adjusted IPSS-R (C index 0.71 vs. 0.70). Conclusion: Adjusting blast% to cellularity did not improve prognostication. However, within IPSS-R-defined blast groups, a small subset of patients with relatively higher blast% and hypercellularity may have a worse prognosis than expected.

引用

页码：502 / 507

页数：6

共 41 条

[1]

Agool A, 2006, J NUCL MED, V47, P1592

[2] The myelodysplastic syndromes flow cytometric score: a three-parameter prognostic flow cytometric scoring system [J].