Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff

被引：4
作者：
Ziyatdinova, N., I [1 ]
Kuptsova, A. M. [1 ]
Faskhutdinov, L., I [1 ]
Galieva, A. M. [1 ]
Zefirov, A. L. [2 ]
Zefirov, T. L. [1 ]
机构：
[1] Kazan Volga Reg Fed Univ, Dept Human Hlth Protect, Kazan, Russia
[2] Kazan Fed Med Univ, Dept Normal Physiol, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
hyperpolarization-activated current; isolated heart; chronotropy; coronary flow; rat; CHANNEL INHIBITOR; IVABRADINE; MYOCARDIUM;
D O I：
10.1007/s10517-019-04541-w
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10(-9) M decreased HR by 26.8% (p <= 0.05). In concentrations 10(-8), 10(-7), 10(-6), and 10(-5) M ZD7288 produced minor differently directed effects. In a concentration of 10(-5) M, ZD7288 reduced coronary flow in the isolated heart (p <= 0.01). In other concentrations, the blocker produced no significant effects on coronary flow.
引用
收藏
页码：424 / 427
页数：4
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