Study on the synthesis, physicochemical, electrochemical properties, molecular structure and antifungal activities of the 4-pyrrolidinopyridine Mg(II) meso-tetratolylporphyrin complex

A novel magnesium(II) metalloporphyrin namely the bis(4-pyrrolidinopyridine)[meso-tetra(p- tolyl)porphyrinato)]magnesium(II) dichloromethane desolate complex with the formula [Mg(TTP)(4pypo)(2)]middotCH(2)Cl(2) ( I ) has been synthetized and fully characterized by UV-Vis, fluorescence, IR, H-1 NMR spectroscopy and mass spectrometry. The X-ray molecular structure shows that I presents two molecules (1 and 2) [Mg1(TTP)(4-pypo)2] and [Mg2(TTP)(4-pypo)2] in the asymmetric unit while the Hirshfeld surface analysis on this hexacoordinated Mg(II) porphyrin species indicates that the crystal lattice is mainly sustained by C-H center dot center dot center dot C, C-H center dot center dot center dot Cg (Cg is the centroid of a phenyl ring) and C-H center dot center dot center dot Cl intermolecular interactions. The cyclic voltammetry data of I is also reported. The bioactivity of the H2TTP, the [Mg(TTP)] starting material and [Mg(TTP)(4-pypo)(2)]middotCH(2)Cl(2) ( I ) was evaluated in vitro , by examining their inhibitory effect against three strains of Candida viz. C. albicans, C. glabrata and C. tropicalis with MIC values in the range 2.5 to 10 mu g.mL(-1). The screening of the susceptibility of M. canis and T. rubrum clinical strains on the three porphyrinic derivatives is also reported. (c) 2022 Elsevier B.V. All rights reserved.