Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells

被引：116

作者：

Kojima, H ^{[1
]}

Takeuchi, M ^{[1
]}

Ohta, T ^{[1
]}

Nishida, Y ^{[1
]}

Arai, N ^{[1
]}

Ikeda, M ^{[1
]}

Ikegami, H ^{[1
]}

Kurimoto, M ^{[1
]}

机构：

[1] Hayashibara Biochem Labs Inc, Fujisaki Inst, Okayama 702, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 244卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pleiotropic biological activities of interleukin-18 (IL-18) are mediated by IL-18 receptor (IL-18R). When the ligand binds to the IL-18R, IL-18R initiates a signaling cascade that results in the activation of nuclear factor kappa B (NF-kappa B). When mouse EL-4 cells were exposed to IL-18, IL-1 receptor-associated kinase (IRAK) was recruited to IL-18R and was phosphorylated. In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK. Therefore, we concluded that IL-18/IL-18R-mediated signaling may share the IRAK/TRAF6 pathway through NF-KB activation with the IL-1/IL-1 receptor system. (C) 1998 Academic Press.

引用

页码：183 / 186

页数：4

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