Pd-catalyzed amination of nucleoside arylsulfonates to yield N6-aryl-2,6-diaminopurine nucleosides

被引：53
作者：
Gunda, P
Russon, LM
Lakshman, MK
机构：
[1] CUNY City Coll, Dept Chem, New York, NY 10031 USA
[2] Analyt Branford Inc, Branford, CT 06405 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 46期
关键词：
amination; C-C coupling; nucleosides; palladium; phosphane ligands;
D O I：
10.1002/anie.200460782
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical equation presented). Substituents on both the nucleoside arylsulfonate as well as the aryl amine component have a significant impact on their coupling to form 2,6-diaminopurine-2′-deoxyribonucleosides (see scheme). A systematic study of ligands for the Pd catalysts in amination and C-C cross-coupling reactions gives insight into the structural elements that lead to effective catalysis.
引用
收藏
页码：6372 / 6377
页数：6
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