Glycometabolism Reprogramming of Glial Cells in Central Nervous System: Novel Target for Neuropathic Pain

被引:25
作者
Kong, Erliang [1 ,2 ]
Li, Yongchang [1 ]
Deng, Mengqiu [1 ]
Hua, Tong [1 ]
Yang, Mei [1 ]
Li, Jian [1 ]
Feng, Xudong [2 ]
Yuan, Hongbin [1 ]
机构
[1] Naval Med Univ, Affiliated Hosp 2, Changzheng Hosp, Dept Anesthesiol, Shanghai, Peoples R China
[2] No 988 Hosp Joint Logist Support Force Chinese Peo, Dept Anesthesiol, Zhengzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
inflammation; glycolysis; microglia; astrocyte; synapse; neuropathic pain; glycometabolism reprogramming; SPINAL DORSAL-HORN; TOLL-LIKE RECEPTOR; SYNAPTIC PLASTICITY; GLUTAMATE TRANSPORTERS; GENE-EXPRESSION; PROTEIN-KINASE; LACTATE; METABOLISM; MACROPHAGES; GLYCOLYSIS;
D O I
10.3389/fimmu.2022.861290
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neuropathic pain is characterized by hyperalgesia and allodynia. Inflammatory response is conducive to tissue recovery upon nerve injury, but persistent and exaggerated inflammation is detrimental and participates in neuropathic pain. Synaptic transmission in the nociceptive pathway, and particularly the balance between facilitation and inhibition, could be affected by inflammation, which in turn is regulated by glial cells. Importantly, glycometabolism exerts a vital role in the inflammatory process. Glycometabolism reprogramming of inflammatory cells in neuropathic pain is characterized by impaired oxidative phosphorylation in mitochondria and enhanced glycolysis. These changes induce phenotypic transition of inflammatory cells to promote neural inflammation and oxidative stress in peripheral and central nervous system. Accumulation of lactate in synaptic microenvironment also contributes to synaptic remodeling and central sensitization. Previous studies mainly focused on the glycometabolism reprogramming in peripheral inflammatory cells such as macrophage or lymphocyte, little attention was paid to the regulation effects of glycometabolism reprogramming on the inflammatory responses in glial cells. This review summarizes the evidences for glycometabolism reprogramming in peripheral inflammatory cells, and presents a small quantity of present studies on glycometabolism in glial cells, expecting to promote the exploration in glycometabolism in glial cells of neuropathic pain.
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页数:12
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