Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity

被引：642

作者：

Kandola, Aaron ^{[1
]}

Ashdown-Franks, Garcia ^{[2
,3
]}

Hendrikse, Joshua ^{[4
,5
]}

Sabiston, Catherine M. ^{[6
]}

Stubbs, Brendon ^{[2
,7
]}

机构：

[1] UCL, Div Psychiat, London, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[3] Univ Toronto, Dept Exercise Sci, Toronto, ON, Canada

[4] Monash Univ, Brain Mind & Soc Res Hub, Sch Psychol Sci, Melbourne, Vic, Australia

[5] Monash Univ, Turner Inst Brain & Mental Hlth, Melbourne, Vic, Australia

[6] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada

[7] South London & Maudsley Natl Hlth Serv Fdn Trust, Physiotherapy Dept, London, England

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2019年 / 107卷

关键词：

Exercise; Depression; Mental health; Neuroplasticity; Inflammation; Hippocampus; Oxidative stress; Self-esteem; Self-efficacy; Social support; HPA; Stress; BDNF; Non-pharmacological; C-REACTIVE PROTEIN; ADULT HIPPOCAMPAL NEUROGENESIS; MUSCLE-DERIVED INTERLEUKIN-6; NEUROTROPHIC FACTOR BDNF; GLOBAL SELF-ESTEEM; CARDIORESPIRATORY FITNESS; AEROBIC EXERCISE; OXIDATIVE STRESS; BODY-IMAGE; MENTAL-HEALTH;

D O I：

10.1016/j.neubiorev.2019.09.040

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Physical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise. Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicated in the pathophysiology of depression. We focus on the capacity for exercise to elicit changes in neuroplasticity, inflammation, oxidative stress, the endocrine system, self-esteem, social support and self-efficacy. We also discuss how a better understanding of these mechanisms can inform the way we design and implement exercise-based interventions to maximise their antidepressant effects on an individual basis. We conclude by presenting a conceptual framework of the key biological and psychosocial mechanisms underlying the relationship between physical activity and depressive symptoms, and the moderators and confounders that may influence it.

引用

页码：525 / 539

页数：15

共 265 条

[1] Voluntary exercise protects against stress-induced decreased in brain-derived neurotrophic factor protein expression [J].