Improved brachial artery shear patterns and increased flow-mediated dilatation after low-volume high-intensity interval training in type 2 diabetes

被引：52

作者：

Afousi, Alireza Ghardashi ^{[1
]}

Izadi, Mohammad Reza ^{[2
]}

Rakhshan, Kamran ^{[3
]}

Mafi, Farnoosh ^{[1
]}

Biglari, Soheil ^{[1
]}

Bagheri, Habiballah Gandomkar ^{[4
]}

机构：

[1] Univ Tehran, Dept Exercise Physiol, Fac Phys Educ & Exercise Sci, Tehran, Iran

[2] Univ Shahid Chamran, Fac Phys Educ & Exercise Sci, Dept Exercise Physiol, Ahvaz, Iran

[3] Iran Univ Med Sci, Dept Med Physiol, Fac Med, Tehran, Iran

[4] Islamic Azad Univ, Ahvaz Branch, Dept Exercise Physiol, Ahvaz, Iran

来源：

EXPERIMENTAL PHYSIOLOGY | 2018年 / 103卷 / 09期

关键词：

flow-mediated dilatation; high-intensity interval training; nitric oxide bioavailability; shear rate pattern; ENDOTHELIAL DYSFUNCTION; VASCULAR FUNCTION; BLOOD-PRESSURE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OSCILLATORY SHEAR; EXERCISE; RETROGRADE; DILATION; IMPACT;

D O I：

10.1113/EP087005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Atherosclerosis in patients with type 2 diabetes is characterized by endothelial dysfunction associated with impaired flow-mediated dilatation (FMD) and increases retrograde and oscillatory shear. The present study investigated endothelium-dependent vasodilatation and shear rate in patients with type 2 diabetes at baseline and follow-up after 12weeks of low-volume high-intensity interval training (LV-HIIT) or continuous moderate-intensity training (CMIT). Seventy-five sedentary patients with type 2 diabetes and untreated pre- or stage I hypertension were randomly divided into LV-HIIT, CMIT and control groups. The LV-HIIT group intervention was 12 intervals of 1.5min at 85-90% maximal heart rate (HRmax) and 2min at 55-60% HRmax. The CMIT group intervention was 42min of exercise at 70% HRmax for three sessions per week during 12weeks. High-resolution Doppler ultrasound was used to measure FMD, arterial diameter, anterograde and retrograde blood flow, and shear rate patterns. Brachial artery FMD increased significantly in the LV-HIIT group (3.83 +/- 1.13 baseline, 7.39 +/- 3.6% follow-up), whereas there was no significant increase in the CMIT group (3.45 +/- 0.97 baseline, 4.81 +/- 2.36% follow-up) compared to the control group (3.16 +/- 0.78 baseline, 4.04 +/- 1.28% follow-up) (P<0.05). Retrograde shear in the LV-HIIT group decreased significantly (P<0.05), and no significant decrease in retrograde shear was seen in the CMIT group. Anterograde shear after LV-HIIT increased significantly (P<0.05) but was unchanged in the CMIT group. However, oscillatory shear index in both exercise groups decreased significantly (P=0.029). Nitrite/nitrate (NOx) level increased in both exercise groups, but the increase was greater in the LV-HIIT group (P<0.001). The results indicate that by increasing NOx, HIIT decreases the oscillatory shear-induced improvement in FMD and outward artery remodelling in patients with type 2 diabetes.

引用

页码：1264 / 1276

页数：13

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