Interferon-alpha-2a as a salvage treatment for hemorrhagic enteritis associated with Epstein-Barr Virus reactivation : a case report

被引:1
作者
Lankenau-Vela, D. [1 ,2 ]
De la Garza-Salazar, F. [1 ,2 ]
Colunga-Pedraza, P. [3 ]
Jaime-Villalon, D. [4 ]
机构
[1] Univ Monterrey, Especialidades Med, Escuela Med, Monterrey, Nuevo Leon, Mexico
[2] Hosp Christus Muguerza Alta Especialidad, Dept Med Interna, Monterrey, Nuevo Leon, Mexico
[3] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Hematol Serv, Monterrey, Mexico
[4] Hosp Christus Muguerza Alta Especialidad, Infectol Serv, Monterrey, Nuevo Leon, Mexico
关键词
Epstein-barr virus reactivation; interferon; hemorrhagic enteritis; case report; THERAPY; ALPHA; INFECTION;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Epstein-Barr virus [EBV] is a virus that infects almost all humans worldwide. After the acute phase of the infection, it stays in a latent form in B lymphocytes. EBV reactivation tends to occur in immunosuppressed patients. EBV reactivation may involve the gastrointestinal tract; it has been associated mainly with colitis, but hemorrhagic enteritis has been poorly reported. Treatment usually includes antivirals. However, our patient did not respond to conventional treatment, so interferon alpha-2a was given as a salvage treatment. To our knowledge, this is the first reported case of hemorrhagic enteritis associated to EBV reactivation treated successfully with interferon alpha-2a.
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收藏
页码:129 / 130
页数:2
相关论文
共 12 条
[1]  
Busschaert J, 2019, ACTA GASTRO-ENT BELG, V82, P552
[2]   MAJOR THERAPEUTIC USES OF INTERFERONS [J].
CIRELLI, R ;
TYRING, SK .
CLINICAL IMMUNOTHERAPEUTICS, 1995, 3 (01) :27-87
[3]   Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis [J].
Li, Hongde ;
Liu, Sufang ;
Hu, Jianmin ;
Luo, Xiangjian ;
Li, Namei ;
Bode, Ann M. ;
Cao, Ya .
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2016, 12 (11) :1309-1318
[4]  
Matsumoto Hiroshi, 2014, Case Rep Gastroenterol, V8, P240, DOI 10.1159/000365546
[5]  
Pico, 1998, Oncologist, V3, P446
[6]   Interferon alpha as antiviral therapy in chronic active Epstein-Barr virus disease with interstitial pneumonia - case report [J].
Rolinski, Jacek ;
Grywalska, Ewelina ;
Pyzik, Aleksandra ;
Dzik, Michal ;
Opoka-Winiarska, Violetta ;
Surdacka, Agata ;
Maj, Maciej ;
Burdan, Franciszek ;
Pirozynski, Michal ;
Grabarczyk, Piotr ;
Staroslawska, Elzbieta .
BMC INFECTIOUS DISEASES, 2018, 18
[7]   Epstein-Barr Virus Infection Is Common in Inflamed Gastrointestinal Mucosa [J].
Ryan, Julie L. ;
Shen, You-Jun ;
Morgan, Douglas R. ;
Thorne, Leigh B. ;
Kenney, Shannon C. ;
Dominguez, Ricardo L. ;
Gulley, Margaret L. .
DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (07) :1887-1898
[8]   Interferon-α therapy for chronic active Epstein-Barr virus infection:: Potential effect on the development of T-lymphoproliferative disease [J].
Sakai, Y ;
Ohga, S ;
Tonegawa, Y ;
Takada, H ;
Nakao, F ;
Nakayama, H ;
Aoki, T ;
Yamamori, S ;
Hara, T .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1998, 20 (04) :342-346
[9]  
Sarwari Nawid M, 2016, BMC Hematol, V16, P19, DOI 10.1186/s12878-016-0059-3
[10]   Epstein-Barr virus-associated enteritis with multiple ulcers after stem cell transplantation: First histologically confirmed case [J].
Tashiro, Yukie ;
Goto, Masamichi ;
Takemoto, Yoshinobu ;
Sato, Eiichi ;
Shirahama, Hiroshi ;
Utsunomiya, Atae ;
Eizuru, Yoshito ;
Yonezawa, Suguru .
PATHOLOGY INTERNATIONAL, 2006, 56 (09) :530-537