Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata

被引：45

作者：

Fatima, Itrat

Ahmad, Ijaz

Anis, Itrat

Malik, Abdul ^{[1
]}

Afza, Nighat

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[2] Med Bot Ctr, PCSIR Labs, Peshawar, NWFP, Pakistan

[3] PCSIR Labs Complex, Pharmaceut Res Ctr, Karachi 75270, Pakistan

来源：

MOLECULES | 2007年 / 12卷 / 02期

关键词：

Isatis costata; Brassicaseae; oxindole alkaloids; structure elucidation; antifungal activity;

D O I：

10.3390/12020155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.

引用

页码：155 / 162

页数：8

共 11 条

[1]

CHOUDHARY MI, 1995, PHYTOCHEMISTRY, V40, P1243, DOI 10.1016/0031-9422(95)00429-B

[2]

Fatima I, 2006, HETEROCYCLES, V68, P1421

[3]

Jiangsu New Medical College, 1985, DICT CHIN CRUD DRUGS, P1250

[4] New indole derivatives with free radical scavenging activity from Agrocybe cylindracea [J].

Kim, WG ;

Lee, IK ;

Kim, JP ;

Ryoo, IJ ;

Koshino, H ;

Yoo, ID .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (07) :721-723

[5]

KOBAYASHI M, 1994, CHEM PHARM BULL, V42, P2449

[6]

*MIN PUBL HLTH, 1990, CHIN PHARM 1, P172

[7]

NASIR YJ, 1989, NATL HERBARIUM PAKIS, V191, P94

[8]

PINKAS M, 1996, PLANTS MED CHINOISES, P86

[9] REACTIONS WITH INDOLE-DERIVATIVES .26. STERIC COURSE OF METHYLENE-LACTAM REARRANGEMENTS IN RIGID POLICYCLIC SYSTEMS [J].

THIELKE, D ;

WEGENER, J ;

WINTERFELDT, E .

CHEMISCHE BERICHTE-RECUEIL, 1975, 108 (06) :1791-1802

[10]

WING SC, 2005, J ORG CHEM, V70, P3741

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