Deep-probe metal-clad waveguide biosensors

被引：72
作者：
Skivesen, N.
Horvath, R.
Thinggaard, S.
Larsen, N. B.
Pedersen, H. C. [1 ]
机构：
[1] Riso Natl Lab, Opt & Plasma Res Dept, DK-4000 Roskilde, Denmark
[2] Danish Polymer Ctr, Riso Natl Lab, DK-4000 Roskilde, Denmark
来源：
BIOSENSORS & BIOELECTRONICS | 2007年 / 22卷 / 07期
关键词：
biosensors; waveguide sensors; refractometry; cell detection;
D O I：
10.1016/j.bios.2006.05.025
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Two types of metal-clad waveguide biosensors, so-called dip-type and peak-type, are analyzed and tested. Their performances are benchmarked against the well-known surface-plasmon resonance biosensor, showing improved probe characteristics for adlayer thicknesses above 150-200 nm. The dip-type metal-clad waveguide sensor is shown to be the best all-round alternative to the surface-plasmon resonance biosensor. Both metal-clad waveguides are tested experimentally for cell detection, showing a detection linut of 8-9 cells/mm(2). (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：1282 / 1288
页数：7
相关论文
共 27 条
[1]   INTEGRATED OPTICAL YOUNG INTERFEROMETER [J].
BRANDENBURG, A ;
HENNINGER, R .
APPLIED OPTICS, 1994, 33 (25) :5941-5947
[2]   Fuzzy nanoassemblies: Toward layered polymeric multicomposites [J].
Decher, G .
SCIENCE, 1997, 277 (5330) :1232-1237
[3]   Fabrication and packaging of integrated chemo-optical sensors [J].
Heideman, RG ;
Veldhuis, GJ ;
Jager, EWH ;
Lambeck, PV .
SENSORS AND ACTUATORS B-CHEMICAL, 1996, 35 (1-3) :234-240
[4]   Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing [J].
Horvath, R ;
Pedersen, HC ;
Skivesen, N ;
Selmeczi, D ;
Larsen, NB .
APPLIED PHYSICS LETTERS, 2005, 86 (07) :1-3
[5]   Optical waveguide sensor for on-line monitoring of bacteria [J].
Horváth, R ;
Pedersen, HC ;
Skivesen, N ;
Selmeczi, D ;
Larsen, NB .
OPTICS LETTERS, 2003, 28 (14) :1233-1235
[6]   Application of the optical waveguide lightmode spectroscopy to monitor lipid bilayer phase transition [J].
Horváth, R ;
Fricsovszky, G ;
Papp, E .
BIOSENSORS & BIOELECTRONICS, 2003, 18 (04) :415-428
[7]   Reverse-symmetry waveguides:: theory and fabrication [J].
Horváth, R ;
Lindvold, LR ;
Larsen, NB .
APPLIED PHYSICS B-LASERS AND OPTICS, 2002, 74 (4-5) :383-393
[8]   Demonstration of reverse symmetry waveguide sensing in aqueous solutions [J].
Horváth, R ;
Pedersen, HC ;
Larsen, NB .
APPLIED PHYSICS LETTERS, 2002, 81 (12) :2166-2168
[9]   Optical waveguide lightmode spectroscopy as a new method to study adhesion of anchorage-dependent cells as an indicator of metabolic state [J].
Hug, TS ;
Prenosil, JE ;
Morbidelli, M .
BIOSENSORS & BIOELECTRONICS, 2001, 16 (9-12) :865-874
[10]   OPTICAL CHARACTERIZATION OF GOLD USING SURFACE-PLASMON POLARITONS [J].
INNES, RA ;
SAMBLES, JR .
JOURNAL OF PHYSICS F-METAL PHYSICS, 1987, 17 (01) :277-287
123