Prevention of cardiovascular disease in type-2 diabetes: How to improve the clinical efficacy of aspirin

被引:50
作者
Evangelista, V
Totani, L
Rotondo, S
Lorenzet, R
Tognoni, G
De Berardis, G
Nicolucci, A
机构
[1] Consorzio Mario Negri Sud, Lab Vasc Biol & Pharmacol, I-66030 Santa Maria Imbaro, Italy
[2] Consorzio Mario Negri Sud, Antonio Taticchi Unit Cellular & Mol Biol Coagula, I-66030 Santa Maria Imbaro, Italy
[3] Consorzio Mario Negri Sud, Dept Clin Pharmacol & Epidemiol, I-66030 Santa Maria Imbaro, Italy
关键词
diabetes/metabolic disorders; inflammatory mediators; platelet pharmacology;
D O I
10.1160/TH04-07-0453
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atherosclerotic cardiovascular disease and its thrombotic complications are the principal causes of morbidity and mortality in patients with type-2 diabetes. Aspirin reduces the risk of thrombotic events in a broad range of patients with vascular disease and, in selected individuals, is beneficial for primary prevention. Although recommended by existing guidelines, in secondary and in primary prevention trials the clinical efficacy of low-dose as-pirin in patients with diabetes appears to be substantially lower than in individuals without diabetes. In this review, we discuss possible mechanisms that may contribute to reduce the antithrombotic activity of aspirin in diabetes. We also discuss adjuvant therapies used in diabetic patients that may potentially improve the antithrombotic efficacy of aspirin.
引用
收藏
页码:8 / 16
页数:9
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