BIOLOGICAL ACTIVITY AND THERMAL STABILITY OF MONOAND BINUCLEAR COMPLEXES OF PLATINUM (II) WITH AMINO ACIDS

The antiproliferative ability of synthesized platinum (II) binuclear complexes with amino acids (glycine, alanine, and valine) was investigated. The ability was studied against two tumor cell lines of lymphoma L1210 and mastocytoma P815. Cytotoxic activity of the complex increases with an increase in the length of the amino acid radical. The binuclear complex of platinum with valine suppresses the proliferative activity of tumor cells of both lines without dose dependence. At a dose of 0.5 mu g/ml, the cytotoxic effect of the complex with valine in relation to lymphoma cells L1210 is comparable to cisplatin, in relation to mastocytoma cells P815 is reduced by 1.8 times. Complex compounds of platinum with glycine and alanine exhibit biological activity, but have a weak effect on the suppression of the growth of tumor cells of both lines. Synchronous thermal analysis of mono-and binuclear complexes is carried out. The thermal decomposition of the complexes occurs in the temperature range from 200 to 550 degrees C and is accompanied by exothermic effects, in contrast to free amino acids, for which endothermic effects are observed. The enthalpy of exoeffects for binuclear complexes of platinum (II) with amino acids lies in the range from 1463 to 2645 J/g. The introduction of the aliphatic part into the amino acid leads to smoothing of the exothermic peaks for the complexes. The difference in the value of the enthalpy of exothermic effects for binuclear and mononuclear platinum (II) complexes decreases with the growth of the amino acid ligand chain. For monomeric Pt (II) complex compounds with two N-coordinated amino acids, the enthalpy of the exothermic effects does not differ significantly and lies in the range of 3335-3586 J/g.