Studies on the reaction between N-phosphoryl amino acids and ribonucleosides

被引：0

作者：

Hu, JJ ^{[1
]}

Ju, Y ^{[1
]}

Zhao, YF ^{[1
]}

机构：

[1] Tsing Hua Univ, Sch Life Sci & Engn, Dept Chem, Bioorgan Phosphorus CHem Key Lab Educ Minist, Beijing 100084, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2000年 / 21卷 / 11期

关键词：

N-phosphoryl amino acids; nucleotide; peptide; origin of life; primordial genetic code;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction between N-phosphoryl amino acids and nucleosides in aqueous medium was studied and the products were analyzed on the basis of HPLC and LC-MS-MS techniques. The results demonstrated that peptides and oligonucleotides were simultaneously formed. Different selectivities were observed between the reaction of various kinds of N-phosphoryl amino acids and different nucleosides, The results gave some clue for the chemical characteristics of the origin of primordial genetic code.

引用

页码：1667 / 1670

页数：4

共 23 条

[1] BODANSKY M, 1988, PEPTIDE CHEM, P55
[2] EGGLESTON IM, 1989, AMINO ACIDS PEPTIDES, V20, P65
[3] Oligomerization of N,O-bis(trimethylsilyl)-α-amino acids into peptides mediated by o-phenylene phosphorochloridate
Fu, H
Li, ZL
Zhao, YF
Tu, GZ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (02) : 291 - 295
[4] GAIT MJ, 1984, OLIGONUCLEOTIDE SYNT, P1
[5] JI GJ, 1988, SYNTHESIS-STUTTGART, P444
[6] JONES J, 1994, INT SERIES MONOGRAPH, V23, P1
[7] Phosphoryl promotion and differentiation effect on amino acids and prebiotic synthesis of protein
Ju, Y
Zhao, YF
Sha, YW
Tan, B
[J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1995, 101 (1-4): : 117 - 123
[8] JU Y, 1995, CHINESE CHEM LETT, V63, P209
[9] KNORRE DG, 1994, DESIGN TARGETED REAC, P101
[10] BETA-CARBOXYL CATALYTIC EFFECT OF N-PHOSPHORYL ASPARTIC-ACID
LI, YM
ZHANG, DQ
ZHANG, HW
JI, GJ
ZHAO, YF
[J]. BIOORGANIC CHEMISTRY, 1992, 20 (04) : 285 - 295

← 1 2 3 →