Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study

被引：19

作者：

Liu, Yue ^{[1
]}

Wang, Jieqiong ^{[2
,3
]}

Zhang, Jishui ^{[4
]}

Wen, Hongwei ^{[2
,3
]}

Zhang, Yue ^{[1
]}

Kang, Huiying ^{[1
]}

Wang, Xu ^{[4
]}

Li, Wenfeng ^{[1
]}

He, Huiguang ^{[2
,3
,5
]}

Peng, Yun ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Natl Ctr Childrens Hlth, Beijing, Peoples R China

[2] Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Natl Ctr Childrens Hlth, Beijing, Peoples R China

[5] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

OLD-WORLD MONKEY; BASAL GANGLIA; FUNCTIONAL CONNECTIVITY; REGIONAL HOMOGENEITY; NETWORKS; ABNORMALITIES; CORTEX; INDIVIDUALS; PARVALBUMIN; FLUCTUATION;

D O I：

10.1038/s41598-017-04148-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naive and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.

引用

页数：8

共 53 条

[21] Decreased Number of Parvalbumin and Cholinergic Interneurons in the Striatum of Individuals with Tourette Syndrome [J].