Cationic transfection lipids

被引：72
|
作者：
Liu, DX
Ren, T
Gao, X
机构：
[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
[2] TransTech Pharma Inc, High Point, NC 27265 USA
来源：
CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 14期
关键词：
cationic lipids; gene delivery; gene therapy; liposomes; nonviral vectors; transfection;
D O I：
10.2174/0929867033457386
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.
引用
收藏
页码：1307 / 1315
页数：9
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