Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives

被引：16

作者：

del Amo, David Soriano ^{[1
]}

Wang, Wei ^{[1
]}

Besanceney, Christen ^{[1
]}

Zheng, Tianqing ^{[1
]}

He, Yizheng ^{[1
]}

Gerwe, Brian ^{[2
]}

Seidel, Ronald D., III ^{[2
]}

Wu, Peng ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Macromol Therapeut Dev Facil, Bronx, NY 10461 USA

来源：

CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Chemoenzymatic synthesis; Transferases; Fucose; Sialic acid; ENZYMATIC-SYNTHESIS; OLIGOSACCHARIDES; DETERMINANT; NUCLEOTIDE; PATHWAY; ELAM-1; SET; LEX;

D O I：

10.1016/j.carres.2010.03.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combination of recombinant FKP and alpha-(1 -> 3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5'-diphosphate-beta-L-fucose (GDP-fucose), or its analogues can be generated in situ by cofactor recycling using pyruvate kinase. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1107 / 1113

页数：7

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