SIGNIFICANCE OF SELECTED ANTIOXIDANT ENZYMES IN CANCER CELL PROGRESSION

被引：45

作者：

Buldak, Rafal Jakub ^{[1
]}

Buldak, Lukasz ^{[2
]}

Kukla, Michal ^{[3
]}

Gabriel, Andrzej ^{[4
]}

Zwirska-Korczala, Krystyna ^{[1
]}

机构：

[1] Med Univ Silesia, Sch Med, Dept Physiol, Div Dent, Katowice, Poland

[2] Med Univ Silesia, Sch Med, Dept Internal Med & Clin Pharmacol, Katowice, Poland

[3] Med Univ Silesia, Sch Med, Dept Gastroenterol & Hepatol, Katowice, Poland

[4] Med Univ Silesia, Sch Med, Dept Pathomorphol, Div Dent, Katowice, Poland

来源：

POLISH JOURNAL OF PATHOLOGY | 2014年 / 65卷 / 03期

关键词：

antioxidant enzymes; reactive oxygen species; cancer progression; lipid peroxidation; ROS-mediated treatment of cancer; MANGANESE SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; GLUTATHIONE DEPLETION; LIPID-PEROXIDATION; INDUCED APOPTOSIS; CARCINOMA-CELLS; GASTRIC-CANCER; GLIOMA-CELLS; IN-VITRO;

D O I：

10.5114/PJP.2014.45779

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Antioxidant enzymes (AOEs), including superoxide dismutase isoenzymes (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) along with glutathione reductase (GR), reduced glutathione (GSH) and glutathione transferase (GST), are thought to be necessary for life processes in all oxygen-metabolizing cells by removing reactive oxygen species (ROS). The biological significance of AOEs in transformed cells is still unclear, but their capacity to survive may be affected by changes in cellular processes such as proliferation, invasiveness, migration, apoptosis and drug resistance. This review summarizes the significance of antioxidant enzymes in cancer cell progression mainly in an in vitro context.

引用

页码：167 / 175

页数：9

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