Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

被引：164

作者：

de Souza, J. Brian ^{[1
,2
]}

Hafalla, Julius C. R. ^{[1
]}

Riley, Eleanor M. ^{[1
]}

Couper, Kevin N. ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Immunol Unit, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] UCL, Sch Med, Dept Immunol & Mol Pathol, London W1T 4JF, England

来源：

PARASITOLOGY | 2010年 / 137卷 / 05期

基金：

英国医学研究理事会;

关键词：

cerebral malaria; murine model; pathogenesis; TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; FALCIPARUM-INFECTED ERYTHROCYTES; MICROVASCULAR ENDOTHELIAL-CELLS; CD8(+) T-CELLS; NITRIC-OXIDE BIOAVAILABILITY; PLASMODIUM-BERGHEI ANKA; FACTOR-ALPHA; PARASITE SEQUESTRATION; LYMPHOTOXIN-ALPHA;

D O I：

10.1017/S0031182009991715

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the parasitological and immunological events within the brain that lead to the onset of clinical symptoms. Experimental murine models have been used to investigate the sequence of events that lead to cerebral malaria, but there is significant debate on the merits of these models and whether their study is relevant to human disease. Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.

引用

页码：755 / 772

页数：18

共 181 条

[1] Differential binding of clonal variants of Plasmodium falciparum to allelic forms of intracellular adhesion molecule 1 determined by flow adhesion assay [J].