GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue

被引：50

作者：

Song, Tongxing ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Zhou, Yuanfei ^{[1
,2
]}

Wei, Hongkui ^{[1
,2
]}

Peng, Jian ^{[1
,2
]}

机构：

[1] Huazhong Agr Univ, Dept Anim Nutr & Feed Sci, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China

[2] Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 15期

基金：

中国国家自然科学基金;

关键词：

GPR120; Fatty acids; White adipose tissue; Brown adipose tissue; Adipogenesis; Glucose uptake; Metabolic homeostasis; FREE FATTY-ACIDS; COUPLED RECEPTOR 120; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION; PPAR-GAMMA; MACROPHAGE ACCUMULATION; INTRACELLULAR CALCIUM; PROMOTES ADIPOGENESIS; DOCOSAHEXAENOIC ACID; IN-VIVO;

D O I：

10.1007/s00018-017-2492-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that adipose tissue has a critical role in the development of obesity and metabolic diseases and that adipose tissue acts as an endocrine organ to regulate lipid and glucose metabolism. Accumulating in the adipose tissue, fatty acids serve as a primary source of essential nutrients and act on intracellular and cell surface receptors to regulate biological events. G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin resistance. In this review, we summarize recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. We offer a new perspective by comparing the different roles in a variety of homeostatic processes from adipogenic development to adipocyte metabolism, and we also discuss the effects of natural and synthetic agonists that may be potential agents for the treatment of metabolic diseases.

引用

页码：2723 / 2733

页数：11

共 82 条

[1] Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction [J].

Boden, G ;

Shulman, GI .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 :14-23

[2] The role of MAPKs in adipocyte differentiation and obesity [J].

Bost, F ;

Aouadi, M ;

Caron, L ;

Binétruy, B .

BIOCHIMIE, 2005, 87 (01) :51-56

[3] Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules [J].

Briscoe, Celia P. ;

Peat, Andrew J. ;

McKeown, Stephen C. ;

Corbett, David F. ;

Goetz, Aaron S. ;

Littleton, Thomas R. ;

McCoy, David C. ;

Kenakin, Terry P. ;

Andrews, John L. ;

Ammala, Carina ;

Fornwald, James A. ;

Ignar, Diane M. ;

Jenkinson, Stephen .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (05) :619-628

[4] Hyperhomocysteinemia in type 2 diabetes - Relationship to macroangiopathy, nephropathy, and insulin resistance [J].

Buysschaert, M ;

Wallemacq, PE ;

Dramais, AS ;

Hermans, MP .

DIABETES CARE, 2000, 23 (12) :1816-1822

[5] Brown adipose tissue: Function and physiological significance [J].

Cannon, B ;

Nedergaard, J .

PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359

[6] Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism [J].

Cao, Haiming ;

Gerhold, Kristin ;

Mayers, Jared R. ;

Wiest, Michelle M. ;

Watkins, Steven M. ;

Hotamisligil, Goekhan S. .

CELL, 2008, 134 (06) :933-944

[7] Transcription factor C/EBPβ promotes the transcription of the porcine GPR120 gene [J].

Chen, Kun ;

Zhou, Ji-Dan ;

Zhang, Feng ;

Zhang, Fang ;

Zhang, Rui-Rui ;

Zhan, Meng-Si ;

Tang, Xiao-Yin ;

Deng, Bing ;

Lei, Ming-Gang ;

Xiong, Yuan-Zhu .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2016, 56 (02) :91-100

[8] Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity [J].

Cintra, Dennys E. ;

Ropelle, Eduardo R. ;

Moraes, Juliana C. ;

Pauli, Jose R. ;

Morari, Joseane ;

de Souza, Claudio T. ;

Grimaldi, Renato ;

Stahl, Marcela ;

Carvalheira, Jose B. ;

Saad, Mario J. ;

Velloso, Licio A. .

PLOS ONE, 2012, 7 (01)

[9] Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner [J].

Cornall, Lauren M. ;

Mathai, Michael L. ;

Hryciw, Deanne H. ;

McAinch, Andrew J. .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2011, 28 (05) :949-958

[10] Failure of adipocyte differentiation causes type II diabetes mellitus? [J].

Danforth, E .

NATURE GENETICS, 2000, 26 (01) :13-13

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