One year in review 2021: pathogenesis of rheumatoid arthritis

被引：4

作者：

Testa, D. ^{[1
]}

Calvacchi, S. ^{[2
]}

Petrelli, F. ^{[1
]}

Giannini, D. ^{[1
]}

Bilia, S. ^{[1
]}

Alunno, A. ^{[2
]}

Puxeddu, I. ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Immunoallergol Unit, Pisa, Italy

[2] Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2021年 / 39卷 / 03期

关键词：

rheumatoid arthritis; genes; environmental factors; innate immunity; adaptive immunity; pathogenesis; FIBROBLAST-LIKE SYNOVIOCYTES; SYNOVIAL FIBROBLASTS; CELLS; PROLIFERATION; IMBALANCE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and systemic inflammation where the close interaction between immune cells and soluble mediators leads to amplification and perpetuation of inflammatory and remodelling processes. The research carried out in the last year in the field of RA has made it possible to identify new mechanisms involved in the pathogenesis of the disease, enabling the discovery of new potential therapeutic targets. Thus, in this review we summarise new insights in RA pathogenesis, resulting from a literature research date published in the last year.

引用

页码：445 / 452

页数：8

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