Overexpression of CXCR1/CXCR2 on mesenchymal stromal cells may be an effective treatment for acute myocardial infarction

被引：8
作者：
Xu, Jianzhong [1 ]
Chen, Qizhi [1 ]
Shi, Chunzhi [1 ]
Yin, Zhaofang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Cardiol, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China
来源：
CYTOTHERAPY | 2009年 / 11卷 / 08期
关键词：
acute myocardial infarction; CXCR1/CXCR2; receptors; interleukin-8; mesenchymal stromal cells; CHEMOKINE RECEPTORS; RAT MYOCARDIUM; BONE-MARROW; EXPRESSION; ISCHEMIA; REPAIR; CXCR4; GENE;
D O I：
10.3109/14653240903233099
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Bone marrow (BM)-derived mesenchymal stromal (MS() participate in myocardial repair following myocardial infarction (MI). However; their reparative capability is limited, partly because of poor homing abilities. MI is associated with an inflammatory reaction. Interleukin-8 (EA) appears to have a fundamental role in regulating neutrophil localization in ischemic tissues through binding CXCR1/CXCR2 receptors, which show major expression on neutrophils. We hypothesize that the application of IL-8 will enhance the recruitment of overexpressing CXCR1/CXCR2 MSC to sites of degenerated tissue of myocardium, decreasing the ischemic region and improving cardiac function.
引用
收藏
页码：990 / 991
页数：2
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