Serum KL-6 in adult patients with polymyositis and dermatomyositis

被引：65
作者：
Kubo, M [1 ]
Ihn, H [1 ]
Yamane, K [1 ]
Kikuchi, K [1 ]
Yazawa, N [1 ]
Soma, Y [1 ]
Tamaki, K [1 ]
机构：
[1] Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan
来源：
RHEUMATOLOGY | 2000年 / 39卷 / 06期
关键词：
ELISA; interstitial lung disease; internal malignancy;
D O I：
10.1093/rheumatology/39.6.632
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. To determine the serum levels of KL-6, a mucin-like high-molecular-weight glycoprotein, in polymyositis/dermatomyositis (PM/DM) patients. Methods. Serum samples from 42 adult PM/DM patients and 38 healthy control subjects were examined using specific enzyme-linked immunosorbent assay (ELISA) systems. Results. The serum levels of KL-6 in the PM/DM patients were significantly higher than those of the healthy controls. The elevated serum KL-6 levels correlated with the presence of interstitial lung disease (ILD) and decreased percentage diffusing capacity of carbon monoxide (%DLco) in the PM/DM patients. The serum KL-6 levels inversely correlated with %DLco and percentage vital capacity. Additionally, the serum KL-6 levels were elevated in five of the seven DM patients with malignant neoplasia. Conclusions. These results suggest that the serum KL-6 level might be a useful serum marker for ILD and internal malignancy in PM/DM.
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页码：632 / 636
页数：5
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