Metabolic reprogramming, caloric restriction and aging

被引：209

作者：

Anderson, Rozalyn M. ^{[1
,2
,3
]}

Weindruch, Richard ^{[1
,2
,3
]}

机构：

[1] Univ Wisconsin, Geriatr Res Educ & Clin Ctr, William S Middleton Mem Vet Hosp, Madison, WI 53705 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53706 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; MITOCHONDRIAL OXYGEN-CONSUMPTION; SKELETAL-MUSCLE CELLS; GENE-EXPRESSION; DIETARY RESTRICTION; ADIPOSE-TISSUE; POSTTRANSLATIONAL MODIFICATIONS; ENERGY-EXPENDITURE; MAMMALIAN TARGET;

D O I：

10.1016/j.tem.2009.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic reprogramming plays a critical role in its mechanism of aging retardation. We herein describe common signatures of CR and suggest how they can slow aging. We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process.

引用

页码：134 / 141

页数：8

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