The prostate cancer prevention trial risk calculator 2.0 performs equally for standard biopsy and MRI/US fusion- guided biopsy

被引：3

作者：

Maruf, M. ^{[1
]}

Fascelli, M. ^{[1
]}

George, A. K. ^{[1
]}

Siddiqui, M. M. ^{[2
]}

Kongnyuy, M. ^{[1
]}

DiBianco, J. M. ^{[1
]}

Muthigi, A. ^{[1
]}

Valayil, S. ^{[1
]}

Sidana, A. ^{[1
]}

Frye, T. P. ^{[1
]}

Kilchevsky, A. ^{[1
]}

Choyke, P. L. ^{[3
]}

Turkbey, B. ^{[3
]}

Wood, B. J. ^{[4
,5
]}

Pinto, P. A. ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, NIH, Urol Oncol Branch, Bldg 10 Hatfield CRC,Room 1-5940, Bethesda, MD 20892 USA

[2] Univ Maryland, Sch Med, Dept Surg, Div Urol, Baltimore, MD 21201 USA

[3] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA

[4] NCI, Ctr Intervent Oncol, Bethesda, MD 20892 USA

[5] NIH, NIH Clin Ctr, Bldg 10, Bethesda, MD 20892 USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2017年 / 20卷 / 02期

关键词：

RESONANCE-ULTRASOUND FUSION; PREDICTION; DIAGNOSIS; ERSPC;

D O I：

10.1038/pcan.2016.46

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx). We sought to assess the performance of the PCPTRC for straitifying PCa risk in a FBx cohort. METHODS: A review of a prospective cohort undergoing MRI and FBx/SBx was conducted. Data from consecutive FBx/SBx were collected between August 2007 and February 2014, and PCPTRC scores using the PCPTRC2.0R-code were calculated. The risk of positive biopsy and high-grade cancer (Gleason >= 7) on biopsy was calculated and compared with overall and high-grade cancer detection rates (CDRs).Receiver operating characteristic curves were generated and the areas under the curves (AUCs) were compared using DeLong's test. RESULTS: Of 595 men included in the study, PCa was detected in 39% (232) by SBx compared with 48% (287) on combined FBx/SBx biopsy. The PCPTRC AUCs for the CDR were similar (P = 0.70) for SBx (0.69) and combined biopsy (0.70). For high-grade disease, AUCs for SBx (0.71) and combined biopsy (0.70) were slightly higher, but were not statistically different (P = 0.55). CONCLUSIONS: In an MRI-screened population of men undergoing FBx, PCPTRC continues to represent a practical method of accurately stratifying PCa risk.

引用

页码：179 / 185

页数：7

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