SOX2 inhibits metastasis in gastric cancer

被引：28

作者：

Chen, Yansu ^{[1
,2
]}

Huang, Yefei ^{[1
,2
]}

Zhu, Liwen ^{[1
]}

Chen, Minjuan ^{[1
]}

Huang, Yulin ^{[1
]}

Zhang, Jianbing ^{[4
]}

He, Song ^{[4
]}

Li, Aiping ^{[1
]}

Chen, Rui ^{[3
]}

Zhou, Jianwei ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Publ Hlth, Ctr Canc, Dept Mol Cell Biol & Toxicol, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China

[2] Xuzhou Med Coll, Sch Publ Hlth, 209 Tongshan Rd, Xuzhou 221002, Peoples R China

[3] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing, Jiangsu, Peoples R China

[4] Nantong Canc Hosp, Dept Pathol, 30 North Tongyang Rd, Nantong 226361, Jiangsu, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2016年 / 142卷 / 06期

基金：

中国国家自然科学基金;

关键词：

SOX2; Gastric cancer; Prognosis; Metastasis; p21; MICROENVIRONMENTAL REGULATION; TUMOR PROGRESSION; DOWN-REGULATION; CELL; EXPRESSION; SURVIVAL; PROTEIN; LUNG; JWA; PROLIFERATION;

D O I：

10.1007/s00432-016-2125-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the potential role of SOX2 in gastric cancer (GC) metastasis. The SOX2 expression was detected using immunohistochemistry on a GC tissue microarray. The correlations of SOX2 expression with clinicopathological factors and 5-year survival were evaluated. To test the role of SOX2 in inhibiting GC metastasis, the cell transwell assay was performed. Real-time PCR and Western blot were used to explore the possible mechanism that SOX2 inhibits GC metastasis. In the present study, SOX2 expression was downregulated in GC tissues when compared to matching normal tissues. Moreover, patients with high SOX2 expression in cancerous tissues had less lymph node metastasis and better treatment outcome. At the subcellular level, SOX2 inhibited the GC cell migration and invasion by upregulating p21 expression. Moreover, SOX2 was determined to associate with the nuclear p21 expression. GC patients with high SOX2 and nuclear p21 expression had synergistically less lymph node metastasis and the better overall survival. Our results suggest that SOX2 is a promising and favorable metastatic biomarker for GC.

引用

页码：1221 / 1230

页数：10

共 48 条

[1] Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma [J].