Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells

被引：105

作者：

Ju, Yi ^{[1
,2
]}

Cui, Jiwei ^{[1
,2
]}

Sun, Huanli ^{[1
,2
,4
]}

Mullner, Markus ^{[3
]}

Dai, Yunlu ^{[1
,2
]}

Guo, Junling ^{[1
,2
]}

Bertleff-Zieschang, Nadja ^{[1
,2
]}

Suma, Tomoya ^{[1
,2
]}

Richardson, Joseph J. ^{[1
,2
,5
]}

Caruso, Frank ^{[1
,2
]}

机构：

[1] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

[3] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia

[4] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Biomed Polymers Lab, Suzhou 215123, Peoples R China

[5] CSIRO Mfg, Private Bag 10, Clayton, Vic 3169, Australia

来源：

BIOMACROMOLECULES | 2016年 / 17卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

DRUG-DELIVERY; CD44-HYALURONAN INTERACTIONS; MOLECULAR-WEIGHT; NANOPARTICLES; NETWORKS; THERAPY; NANOTECHNOLOGY; NANOMEDICINE; CIRCULATION; ADHESIVE;

D O I：

10.1021/acs.biomac.6b00537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prepared by coating phenolic-functionalized hyaluronic acid (HA) and poly(ethylene glycol) (PEG) on calcium carbonate templates, followed by cross-linking the phenolic groups with metal ions and removing the templates. The incorporation of HA significantly enhanced binding and association with a CD44 overexpressing (CD44+) cancer cell line, while the incorporation of PEG reduced nonspecific interactions with a CD44 minimal-expressing (CD44-) cell line. Moreover, high specific targeting to CD44+ cells can be balanced with low nonspecific binding to CD44- cells simply by using an optimized feed-ratio of HA and PEG to vary the content of HA and PEG incorporated into the capsules. Loading an anticancer drug (i.e., doxorubicin) into the obtained capsules resulted in significantly higher cytotoxicity to CD44+ cells but lower cytotoxicity to CD44- cells.

引用

页码：2268 / 2276

页数：9

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