Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study

被引：12

作者：

Lie, Ingrid Anne ^{[1
,2
]}

Kacar, Sezgi ^{[3
]}

Wesnes, Kristin ^{[2
,4
]}

Brouwer, Iman ^{[3
]}

Kvistad, Silje S. ^{[2
,5
]}

Wergeland, Stig ^{[2
,6
]}

Holmoy, Trygve ^{[7
,8
]}

Midgard, Rune ^{[9
]}

Bru, Alla ^{[10
]}

Edland, Astrid ^{[11
]}

Eikeland, Randi ^{[12
,13
]}

Gosal, Sonia ^{[14
]}

Harbo, Hanne F. ^{[7
,15
]}

Kleveland, Grethe ^{[16
]}

Sorenes, Yvonne S. ^{[17
]}

Oksendal, Nina ^{[18
]}

Varhaug, Kristin N. ^{[1
,2
]}

Vedeler, Christian A. ^{[1
,2
]}

Barkhof, Frederik ^{[3
,19
]}

Teunissen, Charlotte E. ^{[20
]}

Bo, Lars ^{[1
,21
]}

Torkildsen, Oivind ^{[1
,2
]}

Myhr, Kjell-Morten ^{[1
,2
]}

Vrenken, Hugo ^{[3
]}

机构：

[1] Univ Bergen, Dept Clin Med, Bergen, Norway

[2] Haukeland Hosp, Dept Neurol, SysMed Neuro, Bergen, Norway

[3] MS Ctr Amsterdam, Dept Radiol & Nucl Med, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[4] St Olavs Univ Hosp, Dept Neurol, Trondheim, Norway

[5] Haukeland Hosp, Dept Immunol & Transfus Med, Bergen, Norway

[6] Haukeland Hosp, Dept Neurol, Norwegian Multiple Sclerosis Registry & Biobank, Bergen, Norway

[7] Univ Oslo, Inst Clin Med, Oslo, Norway

[8] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[9] Molde Hosp, Dept Neurol, Molde, Norway

[10] Stavanger Univ Hosp, Dept Neurol, Stavanger, Norway

[11] Vestre Viken Hosp Trust, Dept Neurol, Drammen, Norway

[12] Sorlandet Hosp Trust, Dept Res & Educ, Kristiansand, Norway

[13] Univ Agder, Fac Hlth & Sport Sci, Grimstad, Norway

[14] Ostfold Hosp Kalnes, Dept Neurol, Gralum, Norway

[15] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[16] Innlandet Hosp Trust, Dept Neurol, Lillehammer, Norway

[17] Haugesund Hosp, Dept Neurol, Haugesund, Norway

[18] Nordland Hosp Trust, Dept Neurol, Bodo, Norway

[19] UCL, Inst Neurol & Healthcare Engn, London, England

[20] Univ Amsterdam, Clin Chem Dept, Neurochem Lab, Amsterdam Neurosci,Med Ctr, Amsterdam, Netherlands

[21] Haukeland Hosp, Norwegian Multiple Sclerosis Competence Ctr, Dept Neurol, Bergen, Norway

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2022年 / 93卷 / 08期

关键词：

MULTIPLE SCLEROSIS; CLINICAL NEUROLOGY; BIOCHEMISTRY; MRI; LIGHT-CHAIN; BIOMARKERS; THERAPY; MARKERS; INJURY;

D O I：

10.1136/jnnp-2021-328568

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The predictive value of serum neurofilament light chain (sNfL) on long-term prognosis in multiple sclerosis (MS) is still unclear. Objective Investigate the relation between sNfL levels over a 2-year period in patients with relapsing-remitting MS, and clinical disability and grey matter (GM) atrophy after 10 years. Methods 85 patients, originally enrolled in a multicentre, randomised trial of omega-3 fatty acids, participated in a 10-year follow-up visit. sNfL levels were measured by Simoa quarterly until month 12, and then at month 24. The appearance of new gadolinium-enhancing (Gd+) lesions was assessed monthly between baseline and month 9, and then at months 12 and 24. At the 10-year follow-up visit, brain atrophy measures were obtained using FreeSurfer. Results Higher mean sNfL levels during early periods of active inflammation (Gd+ lesions present or recently present) predicted lower total (beta=-0.399, p=0.040) and deep (beta=-0.556, p=0.010) GM volume, lower mean cortical thickness (beta=-0.581, p=0.010) and higher T2 lesion count (beta=0.498, p=0.018). Of the clinical outcomes, higher inflammatory sNfL levels were associated with higher disability measured by the dominant hand Nine-Hole Peg Test (beta=0.593, p=0.004). Mean sNfL levels during periods of remission (no Gd+ lesions present or recently present) did not predict GM atrophy or disability progression. Conclusion Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.

引用

页码：849 / 857

页数：9

共 37 条

[1] Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis [J].