Biophysics of Chromatin Remodeling

被引:34
|
作者
Nodelman, Ilana M. [1 ]
Bowman, Gregory D. [1 ]
机构
[1] Johns Hopkins Univ, TC Jenkins Dept Biophys, Baltimore, MD 21218 USA
来源
ANNUAL REVIEW OF BIOPHYSICS, VOL 50, 2021 | 2021年 / 50卷
基金
美国国家卫生研究院;
关键词
nucleosome; histone; SF2; superfamily; Snf2-type ATPase motor; twist defect; bulge/loop propagation; NUCLEOSOME CORE PARTICLE; DNA-BINDING; HISTONE OCTAMER; CRYSTAL-STRUCTURE; SMALL STEP; BASE-PAIR; COMPLEX; SWI/SNF; MECHANISM; TRANSLOCATION;
D O I
10.1146/annurev-biophys-082520-080201
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers. Chromatin remodelers contain helicase-like ATPase motor domains that can translocate along DNA, and a long-standing question in the field is how this activity is used to reposition or slide nucleosomes. In addition to ratcheting along DNA like their helicase ancestors, remodeler ATPases appear to dictate specific alternating geometries of the DNA duplex, providing an unexpected means for moving DNA past the histone core. Emerging evidence supports twist-based mechanisms for ATP-driven repositioning of nucleosomes along DNA. In this review, we discuss core experimental findings and ideas that have shaped the view of how nucleosome sliding may be achieved.
引用
收藏
页码:73 / 93
页数:21
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