Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract

被引：7

作者：

Bouabdallah, Salwa ^{[1
]}

Sghaier, Rabiaa-M. ^{[2
]}

Selmi, Sawssen ^{[3
]}

Khlifi, Daycem ^{[4
]}

Laouini, Dhafer ^{[2
]}

Ben-Attia, Mossadok ^{[1
]}

机构：

[1] Univ Carthage, Fac Sci Bizerta, Environm Biomonitoring Lab LBE LR01 ES14, Jarzouna 7021, Tunisia

[2] Inst Pasteur, Lab Transmiss Control & Immunobiol Infect LR IPT, Tunis, Tunisia

[3] Ctr Borj Cedria Technopol, Lab Bioact Subst, BP 901, Hammam Lif 2050, Tunisia

[4] Univ Toulouse 3, Lab Mol Interact & Chem React & Photochem, UMR CNRS 5623, 118 Route Narbonne, F-31062 Toulouse, France

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2016年 / 1026卷

关键词：

Anti-cancer; ATCM; GC-MS; Cyclotrisiloxane; Gokshur; MTTassay; RP-HPLC; TRIBULUS-TERRESTRIS; NATURAL-PRODUCTS; SAPONINS; ANTIOXIDANT; APOPTOSIS; MEDICINE; PROTEIN; FRUITS; RATS;

D O I：

10.1016/j.jchromb.2015.11.023

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, the potential effect anti tumor and the chemical composition of different fractions of Gokshur was evaluated. Commonly known as puncture vine, it has been used for a long time in both the Indian and traditional Chinese medicine. It is popularly used as a remedy for fertility disorder in Ayurveda. Samples were collected during June September 2014 in the Cap Bon (north east of the northern Tunisia). Different organs were separated and extracted by sequential process to compare and investigate their potential anti-tumor effect. For the first time, we report the antiproliferatif effect of leaves n-butannolic fraction against cancer cell lines. The better anti-tumor fraction (94.76 +/- 1.52%) has been detected and performed by RP-HPLC has shown a great peak area (5578.21 Mau). Novel designed natural derivatives from Gokshur, a cyclotrisiloxane, major compound identified by GC-MS. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：279 / 285

页数：7

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