Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

被引：150

作者：

Khakh, Baljit S. ^{[1
,2
]}

Beaumont, Vahri ^{[3
]}

Cachope, Roger ^{[3
]}

Munoz-Sanjuan, Ignacio ^{[3
]}

Goldman, Steven A. ^{[4
,5
]}

Grantyn, Rosemarie ^{[6
,7
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Neurobiol, Los Angeles, CA 90095 USA

[3] CHDI Management CHDI Fdn, 6080 Ctr Dr, Los Angeles, CA 90045 USA

[4] Univ Rochester, Ctr Translat Neuromed, 601 Elmwood Ave, Rochester, NY 14642 USA

[5] Univ Copenhagen, Ctr Neurosci, DK-2200 Copenhagen N, Denmark

[6] Charite, Exzellenzcluster NeuroCure, Robert Koch Pl 4, D-10115 Berlin, Germany

[7] Charite, Abt Expt Neurol, Robert Koch Pl 4, D-10115 Berlin, Germany

来源：

TRENDS IN NEUROSCIENCES | 2017年 / 40卷 / 07期

关键词：

YAC128 MOUSE MODEL; MUTANT HUNTINGTIN; IN-VIVO; NEURONAL-ACTIVITY; GLUTAMATE UPTAKE; SPINY NEURONS; SYNAPTIC PLASTICITY; STRIATAL ASTROCYTES; TONIC INHIBITION; TRANSGENIC MICE;

D O I：

10.1016/j.tins.2017.05.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.

引用

页码：422 / 437

页数：16

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