Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke A Randomized Trial

被引：60

作者：

Tuttolomondo, Antonino ^{[1
]}

Di Raimondo, Domenico ^{[1
]}

Pecoraro, Rosaria ^{[1
]}

Maida, Carlo ^{[1
]}

Arnao, Valentina ^{[2
]}

Della Corte, Vittoriano ^{[1
]}

Simonetta, Irene ^{[1
]}

Corpora, Francesca ^{[1
]}

Di Bona, Danilo ^{[4
]}

Maugeri, Rosario ^{[3
]}

Iacopino, Domenico Gerardo ^{[3
]}

Pinto, Antonio ^{[1
]}

机构：

[1] Univ Palermo, Internal Med & Cardioangiol Ward, Dipartimento Biomed Med Interna & Specialist, I-90133 Palermo, Italy

[2] Univ Palermo, Dept Expt Med & Clin Neurosci, Clin Neurol Ward, I-90133 Palermo, Italy

[3] Univ Palermo, Neurosurg Sect, Dept Expt Med & Clin Neurosci, I-90133 Palermo, Italy

[4] Univ Bari, Sch & Chair Allergol, Dipartimento Emergenze & Trapianti Organo, Bari, Italy

来源：

MEDICINE | 2016年 / 95卷 / 13期

关键词：

NITRIC-OXIDE SYNTHASE; COA REDUCTASE INHIBITOR; TISSUE-FACTOR; STATINS; EVENTS; SIMVASTATIN; PRAVASTATIN; EXPRESSION; PROTECTION; MORTALITY;

D O I：

10.1097/MD.0000000000003186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins have beneficial effects on cerebral circulation and brain parenchyma during ischemic stroke and reperfusion. The primary hypothesis of this randomized parallel trial was that treatment with 80mg/day of atorvastatin administered early at admission after acute atherosclerotic ischemic stroke could reduce serum levels of markers of immune-inflammatory activation of the acute phase and that this immune-inflammatory modulation could have a possible effect on prognosis of ischemic stroke evaluated by some outcome indicators. We enrolled 42 patients with acute ischemic stroke classified as large arteries atherosclerosis stroke (LAAS) randomly assigned in a randomized parallel trial to the following groups: Group A, 22 patients treated with atorvastatin 80 mg (once-daily) from admission day until discharge; Group B, 20 patients not treated with atorvastatin 80 mg until discharge, and after discharge, treatment with atorvastatin has been started. At 72 hours and at 7 days after acute ischemic stroke, subjects of group A showed significantly lower plasma levels of tumor necrosis factor-alpha, interleukin (IL)-6, vascular cell adhesion molecule-1, whereas no significant difference with regard to plasma levels of IL-10, E-Selectin, and P-Selectin was observed between the 2 groups. At 72 hours and 7 days after admission, stroke patients treated with atorvastatin 80 mg in comparison with stroke subjects not treated with atorvastatin showed a significantly lower mean National Institutes of Health Stroke Scale and modified Rankin scores. Our findings provide the first evidence that atorvastatin acutely administered immediately after an atherosclerotic ischemic stroke exerts a lowering effect on immune-inflammatory activation of the acute phase of stroke and that its early use is associated to a better functional and prognostic profile.

引用

页数：11

共 1 条

[1] Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers
Rashid, Avan Sabir
Huang-Link, Yumin
Johnsson, Marcus
Wetterhall, Simon
Gauffin, Helena
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2022, 18 : 1993 - 2002

← 1 →