Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma

被引：23

作者：

Chen, KS

Hsieh, PW

Hwang, TL

Chang, FR

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Tajen Inst Technol, Pingtung 907, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan

来源：

NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 03期

关键词：

Neolitsea parvigemma; pseudoneolinderane; linderalactone; neutrophil; anti-inflammatory;

D O I：

10.1080/14786410410001714669

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigeninia, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to FMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 mug/mL, respectively.

引用

页码：283 / 286

页数：4

共 12 条

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[2]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[3] Two novel sesquiterpenes from Neolitsea parvigemma [J].