Disrupting the stem cell niche: Good seeds in bad soil

被引：52
作者：
Perry, John M.
Li, Linheng
机构：
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Pathol, Kansas City, KS 66160 USA
来源：
CELL | 2007年 / 129卷 / 06期
关键词：
D O I：
10.1016/j.cell.2007.05.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stem cells reside in a microenvironment or niche that is critical for stem cell maintenance and regulation. But what happens when a stem cell niche is disrupted? In this issue of Cell, two reports (Walkley et al., 2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease.
引用
收藏
页码：1045 / 1047
页数：3
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