Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes

被引：93

作者：

Xie, Zhiyu ^{[1
,3
]}

Liu, Xigong ^{[1
]}

Liu, Lei ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[3] Xuchang Univ, Coll Chem & Chem Engn, Xuchang 461000, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 12期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; TRANSITION-METAL CATALYSIS; ALPHA-AMINO; TERTIARY-AMINES; MOLECULAR-OXYGEN; ASYMMETRIC ALKYNYLATION; VERSATILE APPROACH; ACID CATALYSIS; DUAL CATALYSIS; BRONSTED ACID;

D O I：

10.1021/acs.orglett.6b01328

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed enantioselective cross-coupling of a C-sp3-H moiety (N-aryl glycine ester) with a C-sp-H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural alpha-amino acids.

引用

页码：2982 / 2985

页数：4

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