Phylogenetic Analysis of the 2020 West Nile Virus (WNV) Outbreak in Andalusia (Spain)

被引：18

作者：

Casimiro-Soriguer, Carlos S. ^{[1
,2
]}

Perez-Florido, Javier ^{[1
,2
]}

Fernandez-Rueda, Jose L. ^{[1
]}

Pedrosa-Corral, Irene ^{[3
,4
]}

Guillot-Sulay, Vicente ^{[3
,4
]}

Lorusso, Nicola ^{[5
]}

Martinez-Gonzalez, Luis Javier ^{[6
]}

Navarro-Mari, Jose M. ^{[3
,4
]}

Dopazo, Joaquin ^{[1
,2
,7
,8
]}

Sanbonmatsu-Gamez, Sara ^{[3
,4
]}

机构：

[1] Hosp Virgen Rocio, Fdn Progreso & Salud FPS, Clin Bioinformat Area, Seville 41013, Spain

[2] Hosp Virgen Rocio, Inst Biomed Seville IBIS, Computat Syst Med, Seville 41013, Spain

[3] Hosp Virgen Nieves, Lab Referencia Virus Andalucia, Serv Microbiol, Granada 18014, Spain

[4] Ibs GRANADA, Inst Invest Biosanit, Granada 18012, Spain

[5] Consejeria Salud & Familias, Direcc Gen Salud Publ & Ordenac Farmaceut, Seville 41020, Spain

[6] Univ Granada, Pfizer, Ctr Genom & Oncol Res, GENYO, Granada 18016, Spain

[7] Hosp Virgen Rocio, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Bioinformat Rare Dis BiER, FPS, Seville 41013, Spain

[8] Hosp Virgen Rocio, ELIXIRES FPS, Seville 41013, Spain

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

West Nile Virus; outbreak; meningoencephalitis; epidemiology; phylogeny; whole genome sequencing; GENOME SEQUENCES; DENGUE-VIRUS; REAL-TIME; INFECTION; ALIGNMENT; STRAINS; PROTEIN; EPIDEMIOLOGY; GENERATION; LINEAGES;

D O I：

10.3390/v13050836

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During recent decades West Nile Virus (WNV) outbreaks have continuously occurred in the Mediterranean area. In August 2020 a new WNV outbreak affected 71 people with meningoencephalitis in Andalusia and six more cases were detected in Extremadura (south-west of Spain), causing a total of eight deaths. The whole genomes of four viruses were obtained and phylogenetically analyzed in the context of recent outbreaks. The Andalusian viral samples belonged to lineage 1 and were relatively similar to those of previous outbreaks which occurred in the Mediterranean region. Here we present a detailed analysis of the outbreak, including an extensive phylogenetic study. As part on this effort, we implemented a local Nextstrain server, which has become a constituent piece of regional epidemiological surveillance, wherein forthcoming genomes of environmental samples or, eventually, future outbreaks, will be included.

引用

页数：10

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